Pharmocotherapy Principles and Practice- Thyroid Disorders

Contact Hours: 2.0

ACPE No: 014-999-07-057-H04

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Learning Objectives

Upon completion of this activity the participant should be able to:
On completion of the chapter, the reader will be able to
1. Explain the major components of the hypothalamic-pituitary-thyroid axis and the interaction among these components.
2. Discuss the prevalence of thyroid disorders, including subclinical (mild) and overt (typical signs and/or symptoms present) hypothyroidism and hyperthyroidism.
3. Discuss the relationship between serum thyroid-stimulating hormone (TSH) levels and primary thyroid disease and the advantages for the use of TSH levels over other tests such as serum T4 (thyroxine) and T3 (triiodothyroinine) levels.
4. Identify the typical signs and symptoms of hypothyroidism and the consequences of inadequate treatment.
5. Describe the clinical use of levothyroxine in the treatment of hypothyroidism, including initial dose and dose titration, and patient monitoring.
6. Discuss the issues regarding levothyroxine product bioequivalence and the advantages of maintaining patients on the same product.
7. Identify the typical signs and symptoms of Grave’s disease and the consequences of inadequate treatment.
8. Describe the management of hypothyroidism and hyperthyroidism in pregnant women.
9. Discuss the pharmacotherapy of Grave’s disease, including the advantages and disadvantages of antithyroid drugs versus radioactive iodine, adverse effects, and patient monitoring.
10. Describe the potential effects of amiodarone, lithium, and interferon-α on thyroid function

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